A multinational team of scientists discusses the transformative potential of agroecology, or ecological agricultural practices, and its role in building climate resilience. The article emphasizes that agroecology is a holistic and transformative approach to food systems, with growing evidence of its adaptive and mitigative potential in addressing climate change. It also supports human health and food security by improving nutrition and enabling the cultivation of more resilient, diverse, and nutrient-rich crops. Beyond environmental and health benefits, agroecology offers socio-cultural advantages, including the co-creation of knowledge with farmers, participatory design processes, and collective resource management. It enhances biodiversity, seed diversity, and ecosystem services—for example, by creating mineral balance in the soil through crop rotation, applying compost, using cover crops, and reducing reliance on pesticides and synthetic fertilizers. The article also explores the potential to scale up agroecology through strategic planning, education, supportive policy frameworks, and continued research and experimentation. It highlights agroecology’s ability to strengthen communities, landscapes, and public health, especially in regions vulnerable to climate change.