The video series ‘Breakthrough: Portraits of Women in Science’, profiles Karletta Chief, Chief Hydrologist with the Howard Hughes Medical Institute, and Indigenous woman of the Diné (Navajo) Bitter Water Clan. For many years, Karletta has been leading out work to study the quality and properties of water on the Navajo Nation, an arid region which is home to over 250,000 resident spread across sections of Utah, New Mexico and Arizona. The land has been desecrated for decades by coal and uranium mining, as well as the oil and gas industry. In August 2015, the Gold King Mine spill dumped millions of tons of toxic waste water into local river systems, contaminating the Animas River which is a vital source of life and livelihoods across the region. Karletta is working ceaselessly with the community to address the many issues faced due to this latest toxic water threat. Photo credit: Science Friday